Endocrine Abstracts

Background: Non-alcoholic fatty liver disease (NAFLD) is recognized as common liver disorder that represents the hepatic manifestation of the metabolic syndrome including visceral obesity, type 2 diabetes, insulin resistance and hyperlipidemia. Non-alcoholic steatohepatitis (NASH) is the progressive form of liver injury with the risk for progressive fibrosis, cirrhosis and end-stage liver disease. The pathophysiology that leads to NAFLD and NASH is not well understood. We hypo...

Introduction: Patients with chronic primary adrenal insufficiency (PAI) depend on lifelong gluco- (GC) and mineralocorticoid (MC) replacement therapy. Reduced subjective well-being is however often described by these patients in absence of clinical or laboratory abnormalities and is thus a strong indicator of the gap between the concept of adequate hormone substitution and patients’ requirements. The aim of this study was to investigate the potential role of 23...

BackgroundCushing’s syndrome due to ectopic ACTH secretion only accounts for 10% of all cases of Cushing’s syndrome and is most often associated with pulmonary neuro-endocrine tumors. Treatment of ectopic ACTH syndrome is predominantly surgical with resection of the tumor. Following resolution of hypercortisolism, previously subclinical Pneumocystis jiroveci infection can become overt due to restored immune response.Clini...

Background: Patients with neuroendocrine tumors (NETs) have a 5-year survival rate of 30-60%. Surgery, and newly approved ‘tar-geted radionuclide therapy (TRT)’ with [177Lu]DOTATATE, are the only curative options for patients with NETs. TRT is limited to pa--tients that have high levels of somatostatin receptor subtype 2 (SSTR2) and can im-prove the survival of patients with low-grade tumors, but has little effect on high-grade NETs that express low SSTR2 ...

Background: Various social determinant of health (SDOH) metrics and indices are utilized to evaluate access to cancer care and to explain disparities in outcome in pancreatic neuroendocrine tumors (PNETs). Little prior work has compared the validity of various geographic metrics. Therefore we aimed to examine different geographic metrics validity (from smallest to largest: census block group< census tract< zip code< county) utilizing single institutional data in a ...

Background: Tumor size and lymph node involvement (stage) have been utilized to prognosticate pancreatic neuroendocrine tumors (PNETs) but the influence of race and social vulnerability on these factors remains unexplored. Therefore we sought to explore this in a racially and socioeconomically diverse cohort.Methods: We reviewed records of all patients who underwent surgical resection for PNETs from 2006-2022 at a single NCI-designated cancer center in t...

Introduction: Hypophysitis (Hp) is a serious adverse effect (AE) of Immune check-point inhibitor (ICI) therapy in malignancy. We evaluated 6 yeas of clinical expereince with ICI against the recent ESE CPG 2023 which provides practical guidance on the management of this condition based on up-to-date evidence.Methods: A quality improvement project (QIP) included all patients with ICI-Hp (n=17) referred to a dedicated Endocrine-ICI clinic (January ...

Background: Current theragnostic techniques for pancreatic neuroendocrine tumors (pNETs) exploit the overexpression of somatostatin receptors (SSTRs) on the cell surface. However, approximately 25% of low-grade and most high-grade pNETs do not express SSTRs, requiring alternative theranostics. Calreticulin (CALR) is a protein linked to reticular calcium homeostasis and immunogenic cell death. Upon sufficient cellular insult, CALR translocates from the endoplasmic reticulum (ER...

Background: Pancreatic neuroendocrine tumors (pNETs) are slow growing, malignant tumors that show different survival outcomes by race. They are often diagnosed in late stages, with few treatments available. PNETs are the second most common pancreatic cancer and are rapidly increasing in incidence. Current size-based guidelines were largely developed in White patients and recently have been called into question for Black patients. We investigated differences of primary tumor si...

Background: Preeclampsia (PE) is a complex condition of pregnancy, associated with substantial perinatal morbidity and mortality, affecting 2% to 8% of pregnancies worldwide. Its hallmarks are high blood pressure (hypertension) and endothelial dysfunction, leading to potential end-organ injury. Affected organ systems include liver, blood, kidneys, brain and placenta. In the present study, we investigated steroid hormones such as progestagens, estrogens, androgens, and glucocor...